In the following list, you'll find the most common and easily avoided sources of adverse drug reactions concerning over-the-counter cold and sinus medications. Keep this list handy and review it whenever you're searching for a cold and sinus medication - and ask your pharmacist for advice. Remember to tell your doctor or pharmacist about OTC medicines you're taking before you begin a new prescription drug.
Alcohol-containing cold medications interact with antihistamines or alcohol, causing a strong sedative effect that could cause a coma, or worse. Antihistamines interact with kava or other anti-anxiety meds. Can cause sleepiness, pronounced sedative effect.
Antihistamines interact with some sleep aids, causing a pronounced sedative effect. Some antihistamines interact with some antiarrhythmic drugs and may cause a pronounced change in heart rate leading to serious or life threatening abnormalities in heart rhythm (if you're going to mix these, fill out an organ donation card).
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