Why does blood clot formation increase with age, overweight, and faulty metabolism?

Our body produces plasmin and related products which maintain enzymes with the ability to break up clots by dissolving fibrin, the material that forms blood clots and eventually entangled red cells and platelets to form the clot. As we age, the body produces less plasmin while fibrinogen and fibrin, levels increase. Therefore, the higher the level of fibrinogen, the greater the possibility of developing blood clots.

Furthermore, the older we get the more clotting and the less clot busting ability we have. Increased blood clot formation in millions of Americans each year enhances heart attacks, strokes and limb loss that are a direct or indirect result from unnecessary blood clots, leading to death or permanent disability. Being overweight is an indication of faulty metabolism.

Faulty metabolism that results in high triglyceride and low HDL levels is considered to be a major cause of arteriosclerosis. How does fibrin effect coagulation? Blood clotting occurs when the blood clotting ... more.

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