Why is the Clojure Hello World program so slow compared to Java and Python?

You're not measuring much here except for Clojure boot time. You're also running your program in such a way that you are measuring compilation time as well. If you want to see faster load times you'll need to ahead-of-time compile your code.

To add to dnolen's answer, when doing Python vs Clojure timing contents, you might want to package your "basic unit of work" as a function and then use the time macro (in Clojure) or the timeit. Timeit function (in Python; or, better yet, use the timing facilities of IPython) at the REPL. The results should be roughly comparable.

(Note that Clojure code needs to be "warmed up" by running it a few times to achieve full performance.).

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