Will replacing a computers motherboard wipe clean the hard drive?

The first home computers didn't. They had what is called a backplane, which is basically just a board with a bunch of card slots wired together. All the components of a computer came on separate cards.

You had a CPU card, a video card, a serial/parallel card, a RAM card, disk controller card, and so on. It's just a bajillion times easier and faster to have all that stuff on the main board itself and save the card slots for other things.

They have motherboards so they can properly function without them you wouldn't even be able to log in to your computer to ask this question hope this helps!

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