Most drug screens done by Gas Chromatography target specific drugs or groups of drugs by testing the body's fluids for the metabolites left-over by them. For instance many opioid drugs metabolize into morphine in the body, which can, and is, tested for in the urine, or saliva by GS or by "dipstick" method. Some synthetic narcotic agonists like Methadone or partial agonist/antagonists like Suboxone(Buprenorphine/Naloxone) do not break down to morphine and their metabolites are not caught by the GC unless targeted.
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