It's possible, but you would need to retemplate it to achieve perfection. You can get most of the way there by overriding a system parameter as follows.
All WPF controls are "lookless," so you can completely redefine their appearance. However, it's not simple and even less so for ComboBox. ComboBox uses one of two templates, depending on whether it's editable.
The non-editable version uses the ToggleButton for the control appearance, so you can just remove the arrow drawing (see below). The editable version uses a TextBox and a ToggleButton, and if you have no ToggleButton, it doesn't open. So here's a template without the ToggleButton; it's up to you to add the code to handle clicks on the editable template.
(Or if you don't need to edit, you can just coerce IsEditable to false and be done with it.).
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