For what you're describing, a high-end expensive motherboard with 3 or 4 PCI-E x16 slots for SLI or Crossfire is probably the wrong approach. A $100 motherboard with 2 PCI-E x16 slots is plenty. You're better off going with cards which can natively support 4 monitors each.
Most such models from Nvidia or AMD are fairly high-end (for example there was a GTX 460 from Zotac which could do it, and I'd expect there are $200ish models in the GeForce GTX 560-GTX 660 range which can. On the AMD side, probably an HD 7850 or 7870. But for multiple displays for trading & business, you'll probably want a Matrox card.
Either their PCI-E cards from the M series, or maybe their Triplehead2Go, which splits output from a single DVI, Display Port (or even older VGA port) on existing graphics cards to 3 different monitors. You'll have to check pricing on their multi-display offerings to see which is most cost-effective. I've used their Dualhead2go in the past, it's a great solution for laptops or older computers with built-in graphics which cannot be upgraded with a better card.
But in your case (building from scratch) you can probably find an even better solution. http://www.matrox.com/graphics/en/produc... http://www.matrox.com/graphics/en/produc... Just FYI it appears the Matrox M9148 (which can drive four 2560x1600 monitor) costs about $550 on Amazon, while the M9140 which can only go to 1920x1080 per monitor is $500. So they're pricey.
AMD looks more affordable taking the other approach. You can get a socket AM3+ motherboard with 4 PCI-E x16 slots for about $160. http://www.newegg.com/Product/Product.as... Then you'd be looking at 3 or 4 cards around $60 like a Radeon HD 6570 or GeForce GT 620, which could handle 2 monitors each.
Going with an Intel motherboard that supports quadruple cards means being on socket LGA 2011 so you be spending closer to $300 for the mobo, and CPUs for that socket are considerably more expensive too. Note- in such setups you would NOT be connecting your graphics cards in SLI or Crossfire, just running them independently.
Yes, I know in our reception area at work we have at least that many displays hooked up to the same machine. I actually put that machine together but even so I can't remember how many displays it actually drives - the application sounds fairly similar though, essentially static displays updated periodically although it's surprising how capable each display is. This was perhaps twelve months ago but I remember using Matrox PCIe x1 cards to do it, each driving up to four monitors via a breakout lead.
Looking at their website now it looks like it was M9120s I used... quite pricey as I remember, but they do dual head cards for a lot less, again on ×1 interfaces so you have most scope for loading up a machine with cards. I'd certainly give Matrox a look since it seems it is one thing they really focus on.
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