Are buprenorphine and methadone both effective in the treatment of opiate dependence?

Scientific research shows that both medications are effective for treatment of opiate dependence when combined with counseling and other psycho-social supports. Because of the pharmacologic differences between these two medications and the regulations that affect how they are dispensed, one medication may be more appropriate for certain patients than the other. Under current regulations, for example female patients who are pregnant generally receive methadone in opiate treatment programs.

Although buprenorphine is not approved to treat opiate dependence in pregnant women, it can be prescribed if the physician believes the benefits outweigh the risks. The National institute on Drug Abuse is funding a multi-center trial to compare buprenorphine and methadone treatment for pregnant, opiate-addicted women. If results are equally positive for both medications, data from this trial will be shared with the FDA so both can be approved to treat opiate-addicted pregnant women.

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