Are there any warnings for using opioids, CNS depressors, and stimulants?

According to the National Institute on Drug Abuse, opioids should never be used with substances that cause CNS depression, including: • alcohol • antihistamines • barbiturates • benzodiazepines • general anesthetics CNS depressors should never be used with other substances that depress the CNS, such as: • alcohol • prescription opioid pain medicines • some OTC cold and allergy medications Stimulants should never be used with other substances that stimulate the nervous system, including: • antidepressants, unless supervised by a physician • OTC decongestant medications • some asthma medications more.

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