You are not supposed to because it lessens the strength of the antibiotics. Most of the time, it tells you on the prescription to avoid alcohol.
Sometimes, drinking alcohol while taking antibiotics can alter the behavior of the drug and either increase or decrease it effects. It's always best to read the information that comes with your prescription and to check with your doctor before consuming alcohol with any prescription drug.
Bactrim and alcohol. Micromedex 2.0 Healthcare Series. Accessed Dec. 10, 2014.
Some antibiotics can cause side-effects when taken with alcohol, such as feeling sick, vomiting, headaches and even convulsions.
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