Check the /Bin folder of your application and see if the EPiServer. Framework DLL is there. If it isn't you can set the DLL to "Copy Local" by right clicking on it in the References folder within Solution Explorer and selecting Properties, then set Copy Local to "true".
Now when you build the solution, the DLL will be copied from it's reference location into the Bin folder. You may need to do this for all the EPiServer DLLs.
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