Does estrogen-replacement therapy (ERT) cause cancer?

ERT causes a slight increase in the risk of breast cancer and the risk of uterine cancer in women who have not had a hysterectomy. Some women already may be at a higher-than-normal risk of breast cancer if a family member has had the disease. However, these increased risks are managed easily through regular doctor visits and screenings.

An endometrial biopsy to check the lining of the uterus and look for abnormal bleeding can be done in a doctor’s office. Breast-cancer screenings include regular self-exams and mammograms. Overall, there are generally more benefits with ERT, including a reduced risk of osteoporosis and cardiovascular disease, than drawbacks.

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