How effective is estrogen-replacement therapy (ERT) against bone loss?

For women, estrogen-replacement therapy, or ERT, after menopause is the single most effective prevention for bone loss and osteoporosis. When menopause occurs earlier than age 45 to 55, the risk of fractures increases. The risk is higher if both ovaries are removed before menopause.

Although taking ERT is a decision every woman should make with her doctor, most experts advise taking estrogen unless a family history of breast cancer or other reason makes it dangerous. Estrogen can prevent or at least greatly delay osteoporosis if taken within the first few years after menopause. The dose of estrogen needed to prevent and treat osteoporosis is the equivalent of 0.625 mg conjugated estrogen daily, given for 21 to 25 days each month.

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