Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?

Joffe RT; Sawka AM; Marriott MJ; MacQueen GM; Gernstein HC Department of Psychiatry, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA. [email protected] Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine.

Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone. More.

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