Does the observed HFS-induced potentiation reflect LTP?

In addition to LFS-mediated AP wind-up, we also observed HFS-induced potentiation of neuronal responsiveness in the cultures, in which the response to TS was increased after application of a series of HFS (i.e. , tetanic stimulation). Evidence that tetanic stimulation can induce changes in synaptic activity, such as LTP and long-term depression (LTD), in the dorsal horn was first described by Randic et al.

(1993). During recent years, several groups have presented evidence for induction of LTP in dorsal horn neurons after electrical or noxious stimulation and after nerve injury (Svendsen et al. , 1997; Sandkühler and Liu, 1998).

HFS may also induce "post-tetanic potentiation" (PTP), which resembles LTP but is of shorter duration (minutes to hours); LTP can last from hours to days (Fisher et al. , 1997). PTP has been suggested as a predictor of LTP (Son and Carpenter, 1996), but is thought to be the result primarily of presynaptic mechanisms, whereas LTP is attributable predominantly to ... more.

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