Does vagal nerve stimulation affect body composition and metabolism?

GROUND: It has been shown that vagal nerve stimulation (VNS) can affect body mass. The aim of this study was to evaluate effect of VNS on body mass, body composition, metabolic rate, and plasma leptin and IGF-I levels. METHODS: Eight female pigs were included in the study.

Under general anesthesia, a bipolar electrode was implanted on the anterior vagal nerve by laparoscopy. Group A was treated by VNS, and group B was the control. After 4 weeks, stimulation was discontinued in group A and started in group B.

The following parameters were evaluated: body mass, body composition, metabolic rate, plasma leptin and IGF-1 levels and intramuscular fat content (IMF). RESULTS: VNS attenuated body weight gain (2.28 +/- 2.280 kg vs 12.280 +/- 2.280 kg; P = .0112, for stimulation and nonstimulation periods, respectively), backfat gain (0.04 +/- 0.26 mm vs 2.280 +/- 2.280 mm) and IMF gain (-2.280 +/- 2.280 mg/g MS vs 2.280 +/- 2.280 mg/g MS; P = .0281). VNS resulted in lower backfat depth/loin muscle ... more.

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