Depending on the configuration of the VPN, you may or may not be able to access resources on your local area network. If access to the LAN is blocked, you won't be able to connect to things on your own network. (There is a client setting to allow or disallow access to your LAN, but it can be overridden by settings on the VPN server, or by policies on the network you are connecting to.) In this case, it makes perfect sense that your computer will perform badly any time you try to access one of your own network shares or printers; until the request times out, your computer will be more or less unresponsive.
But why would everything be slow? Try to open your C: drive, and it's slow... try to open Word, and it's slow... try to open the web browser, and it's slow, slow, slow. If this happens, check your profile settings in Active Directory.
If the home directory is on the network, you'll suffer poor performance while connected to the VPN. Why are tasks which shouldn't need to access the ... more.
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