How can a PET scan help detect Alzheimer's disease?

A regular PET scan measures the amount of blood flow and glucose metabolism in the brain, with special emphasis on the temporal lobe where memory function occurs. Decreased blood flow and/or glucose metabolism is an early indicator of Alzheimer’s disease. A still newer, modified PET scan is now beginning to come into use: amyloid PET scanning.

Amyloid plaques in the brain are the most reliable hallmarks of Alzheimer’s disease. Amyloid PET scanning measures the amount of amyloid plaques in the brain; the number of amyloid plaques seen, especially in the temporal and the frontal lobes of the brain, are a measure of the likelihood and the severity of the disease.

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