How does high total cholesterol cause heart disease?

Most people who have high total cholesterol also have high low-density lipoprotein (LDL) cholesterol, which causes arterial aging. LDL molecules deliver cholesterol to the cells in the body. When cholesterol rises, excess LDL molecules in the bloodstream can attach to small ruptures or inflammatory lesions in the artery wall, the endothelium.

This triggers a process that can lead to the development of arterial plaques and cardiovascular aging.

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