The answer depends mainly on the CPU and RAM on the machine running Enfold Server as well as your load balancing needs. Generally, as a conservative estimate, you need to allocate 1-2 gigabytes of RAM per Zope client and have one Zope client per processor on your machine. Note that Enfold Server lets you bind a Zope process to a specific processor when using multiprocessors.
This feature is called process affinity. (Read how to configure Process Affinity). More.
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