How much time/effort are recipients expected to devote?

Principal investigators (PIs) are expected to devote time commensurate to project needs, and follow general guidelines as for other NIH projects of similar size, complexity and duration. PIs of a U54 application are expected to commit 3.6 person months or more effort to ensure success of the program. PIs of a U01 application is expected to commit 3.0 person months or more effort to ensure success of the program.

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I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.