If I work out of town, what can I deduct from my taxes?

I'd talk to a tax adviser to me sure, but in general, the transportation to and from your residence to your job is not deductible. The cost of maintaining the Columbia residence is probably also not deductible, unless you're required by your employer to maintain it, then you might be able to claim that costs that were exclusively related to your employment under a home office deduction. Mileage for work related driving within Charleston would be deductible.

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