Is petadolex helpful in the treatment of migraine headaches?

This standardized extract from the butterbur plant (Petasites hybridus) has been shown in several double-blind studies to produce excellent results as a treatment for migraine headaches, without side effects. In one study, 60 patients with headaches randomly received either 50 mg of Petadolex twice daily for 12 weeks, or a placebo. Petadolex reduced the frequency of attacks by 46 percent after four weeks, 60 percent after eight weeks, and 50 percent after 12 weeks of treatment.

(The results for the placebo group were: 24 percent, 17 percent, and 10 percent, respectively.) Petadolex is generally well tolerated, but diarrhea has been reported in some individuals. If this side effect occurs, discontinue use. Its safety during pregnancy and lactation has not been determined.

The typical adult dosage ranges from 50 to 100 mg twice daily with meals.

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