Should immunoglobulin therapy be used in allogeneic stem-cell transplantation?

Cordonnier C; Chevret S; Legrand M; Rafi H; Dhdin N; Lehmann B; Bassompierre F; Gluckman E; Assistance Publique-Hôpitaux de Paris, Créteil, France. [email protected] BACKGROUND: The universal use of prophylactic immunoglobulin in stem-cell transplantation has not been supported by strong evidence of benefit. Results of most trials were reported before effective drugs for cytomegalovirus infection and disease were available, and no trial was placebo controlled.

OBJECTIVE: To assess the role and the dose-effect relationship of immunoglobulin in the prophylaxis of complications after allogeneic stem-cell transplantation. DESIGN: Multicenter randomized, double-blind, dose effect placebo-controlled study. SETTING: 19 stem-cell transplantation centers in France.

PATIENTS: 200 patients who had allogeneic stem-cell transplantation from HLA-identical sibling donors between 1998 and 2000. INTERVENTION: Immunoglobulin at doses of 50 mg/kg of body weight, 250 mg/kg, or 500 mg/kg weekly ... more.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.