Because coronary artery filling occurs during diastole, people with coronary artery disease (CAD) are at increased risk for coronary ischemic events (insufficient blood flow and oxygenation) when diastolic blood pressure falls below a certain level. This is because when diastolic blood pressure is too low, the heart does not refill adequately with blood during diastole. When international researchers studied 22,000 patients in a 14-country study, they found a striking increase in heart attacks in those whose medications brought the diastolic blood pressure below 84.
Those with a diastolic blood pressure below 60 had 3 times the occurrence of heart attacks compared to those with a diastolic above 80.
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