What are the heart benefits of ACE inhibitor drugs if I have diabetes?

The ADVANCE (Action in Diabetes and Vascular Disease) trial found that treatment with an ACE inhibitor in combination with a diuretic reduced the risk of heart disease in those with diabetes, even if they did not have hypertension. Many doctors and diabetes researchers have begun to ask whether blood-pressure-lowering meds should be considered for every person with diabetes or pre-diabetes, or every person deemed at high risk of heart disease, rather than just those who have high blood pressure. Another major study (the ACCOMPLISH trial, short for "Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension") found that using a combination of an ACE inhibitor with amlodipine, a blood pressure medicine from a different class called the calcium channel blockers, was even more effective in reducing cardiovascular disease risk than the combination of an ACE inhibitor with a diuretic.

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