What are the long term effects of mogadon on sleeping habits?

What are the long term effects of mogadon on sleeping habits Asked by newuser10293912 46 months ago Similar Questions: long term effects mogadon sleeping habits Recent Questions About: long term effects mogadon sleeping habits Health.

Similar Questions: long term effects mogadon sleeping habits Recent Questions About: long term effects mogadon sleeping habits.

Helps sleep in the first week, but after that it doesn't work. Nitrazepam = MogadonNitrazepam (marketed under the trade names Mogadon, Alodorm, Arem, Insoma, Nitrazadon, Nitrados, Ormodon, Paxadorm, Remnos and Somnite) is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative and motor impairing properties.1 Nitrazepam also has anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties.

ToleranceTolerance to a drugs effects occurs after regular exposure to a drug. The mechanism of nitrazepam tolerance may be due to down-regulation of benzodiazepine receptors.39 When tolerance and habituation occurs to nitrazepam its pharmacokinetic profile changes with absorption of the drug slowing down, elimination time increasing and brain concentration of nitrazepam increasing significantly.40 Increased levels of GABA in cerebral tissue and alterations in the activity state of the serotoninergic system occurs as a result of nitrazepam tolerance.41Although tolerance to the sleep inducing properties of nitrazepam develops within a matter of days so to does tolerance to the residual performance impairment. After 6 days of use tolerance to nitrazepam's sleep inducing effects and performance impairing effects occurs.42 One study demonstrated tolerance to the sleep promoting effects of nitrazepam and temazepam after 7 days nightly administration.

Quality of sleep was found to be increased after the first nights administration of either nitrazepam or temazepam but by day 7 quality of sleep was found to have returned to baseline suggesting the development of complete tolerance after 7 days use.43 In mice tolerance to the anticonvulsant properties of nitrazepam developed profoundly and rapidly over 6 days, although some anticonvulsant effects were still apparent after 6 days administration.44 In humans tolerance to the anticonvulsant effects of nitrazepam is a frequent occurrence.45edit Dependence and withdrawalSee also benzodiazepine withdrawal syndromeBenzodiazepine drugs such as nitrazepam can cause dependence and addiction and is what is known as the benzodiazepine withdrawal syndrome. Withdrawal from nitrazepam or other benzodiazepines often leads to withdrawal symptoms which are similar to those seen with alcohol and barbiturates, including delirium tremens.4647 The higher the dose and the longer the drug is taken the greater the risk of experiencing unpleasant withdrawal symptoms. Withdrawal symptoms can however occur at standard dosages and also after short term treatment.

Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regime.48Frequent use of nitrazepam may cause dependence and when the drug is reduced or stopped, withdrawal symptoms occur. Withdrawal symptoms including a worsening of insomnia compared to baseline typically occurs after discontinuation of nitrazepam even after short term single nightly dose therapy.49 Dependence on benzodiazepines such as nitrazepam or temazepam often occurs due to discharging patients from hospital on benzodiazepines who were started on benzodiazepine hypnotics in hospital. It is recommended that hypnotic use in hospital be limited to 5 days to avoid the development of drug dependence and withdrawal insomnia.50After discontinuation of nitrazepam a rebound effect may occur about 4 days after stopping medication.51 Nitrazepam has more side effects than other hypnotic drugs and tolerance to sedative properties and rebound insomnia after discontinuation occurs after only 7 days administration.52 Tolerance to the anticonvulsant and anxiolytic effects also develops rapidly during daily administration.53Abrupt withdrawal after long term use from therapeutic doses of nitrazepam may result in a severe benzodiazepine withdrawal syndrome.

Reports in the medical literature report of two psychotic states developing after abrupt withdrawal from nitrazepam including delirium after abrupt withdrawal of 10 mg of nitrazepam and in another case auditory hallucinations and visual cognitive disorder developed after abrupt withdrawal from 5 mg of nitrazepam and 0.5 mg of triazolam. Gradual and careful reduction of the dosage was recommended to prevent severe withdrawal syndromes from developing.54 Antipsychotics increase the severity of benzodiazepine withdrawal effects with an increase in the intensity and severity of convulsions.55 Depersonalisation has also been reported as a benzodiazepine withdrawal effect from nitrazepam.56Abrupt withdrawal from very high doses is even more likely to cause severe withdrawal effects. Withdrawal from very high doses of nitrazepam may cause severe hypoperfusion of the whole brain with diffuse slow activity on EEG.

After withdrawal, abnormalities in hypofrontal brain wave patterns may persist beyond the withdrawal syndrome suggesting that organic brain damage may occur from chronic high dose abuse of benzodiazepines.57 Sources: http://en.wikipedia.org/wiki/Nitrazepam#Tolerance_dependence_and_withdrawal .

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What are the effects of long term smoking pot. Can it slow growth in 17 yr. Boy.

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