What are the physical effects of the flight or fight response?

The late Hans Selye, MD, of Montreal, best described the peculiar aspect of our reactions to stress over 40 years ago in his book The Stress of Life. He called the phenomenon the General Adaptation Syndrome (GAS), better known as the "flight-or-fight" response. His theory is based on the belief that, biologically, we are animals, and that our biology is based on another, quite distant time.

Whenever animals encounter situations that place demands on their ability to adapt, a chain of identifiable, predictable physical and mental responses take place, all of them regulated by the hypothalamus, a part of the brain that evolved to cope specifically with the rigors of a rough-and-tumble life in the wilds. The hypothalamus wants to keep on being a hypothalamus, and as far as the hypothalamus is concerned, the only realistic response to any source of stress is physical action, usually accompanied by quick thinking, perhaps to run, to fight, to walk long and fast to find shelter or warmth, or to search for a new mate. So the hypothalamus responds at once to any stressor by preparing the body for rigorous physical activity.

It directs the pituitary and adrenal glands to secrete a veritable Mulligan's stew of hormones and neurotransmitters. The most immediate and measurable result of all of these surging chemicals is that your blood pressure shoots up, your heart rate increases, your breathing quickens and deepens, and the small, peripheral blood vessels in your skin constrict, diverting more blood to your working muscles while your face goes pale and your hands grow clammy. Still more blood is diverted to the muscles from various internal organs, particularly the stomach, putting digestion on hold.

Your pupils dilate so you can see better. More glycogen stores in your body are broken down to augment blood sugar levels for immediate energy. Your blood chemistry changes subtly to shorten clotting time in case you're injured, while blood flow to the brain increases and the brain's chemistry changes so you can think more quickly.

Even the body's processes of cell repair and growth are put on hold temporarily during stress; your hypothalamus, after all, sees no point in expending energy on cell repair if you're being chased by something that wants you for dinner. All of these changes result in a state of physical and mental arousal for "flight or fight.

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