What is the role of thrombolytic therapy in stroke?

11. Intravenous thrombolytic therapy is potentially an effective treatment of acute stroke, offering the possibility of early reperfusion of ischaemic cerebral tissue and limitation of infarct size. However, all thrombolytic drugs need to be given early after the onset of symptoms (probably within 6 hours) and involve a risk of cerebral haemorrhage.

There may also be an adverse interaction between streptokinase and aspirin (increased risk of cerebral haemorrhage). 12. Data from 12 randomised controlled trials, involving 3 drugs (streptokinase, urokinase and recombinant tissue plasminogen activator alteplase) and fewer than 4000 subjects, are currently available.

The results suggest an increase in the proportion of patients making a good recovery by 6 months, but a substantial increase in cerebral haemorrhage within the first two weeks. There are insufficient data available at present to determine the optimal drug and dosage required, although the situation should be clearer within ... more.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.