Who should be careful about taking estrogen-containing birth control pills?

Certain women should avoid estrogen-containing birth control pills because of increased risk of serious side effects: Smokers -- because of a higher risk of stroke Individuals who have migraine with aura -- because of a higher risk of stroke Those with a personal or family history of blood clots -- estrogen also increases the risk of clotting Women with breast cancer or a family history of breast cancer -- estrogen can increase the risk of developing breast cancer. Interestingly, taking birth control pills that include both estrogen and a progestin has been shown to reduce your risk for developing ovarian cancer. Progesterone-only birth control pills (sometimes referred to as the mini pill), progesterone-only injection (Depo-Provera), and an intrauterine device (IUD) that releases the synthetic progestogen hormone levonorgestrel (Mirena) are less effective than combination pills at preventing ovulation, and may work as contraceptives by altering cervical mucous thickness.

In general, progesterone-only preparations are less likely to influence menstrual migraine compared with estrogen-containing pills.

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