A woman's sex drive is partially dependent on her level of testosterone-like androgens. When women enter menopause and cease to ovulate, 50 percent of their androgens disappear, leaving only the androgens produced by their adrenal glands to stimulate their sex drive. But adrenal production can decrease with age or medications, too.
Half of all women between ages 42 and 52 lose their interest in sex, are harder to arouse, and experience much less frequent and less intense orgasms, because they have lost 60 percent of the testosterone-like substances they had at age 20. Plus, they have fewer receptors for hormones, so the effects are compounded.
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