Can blood pressure medications help reduce hot flashes?

Hypertension, also known as high blood pressure, is a condition in which the pressure against arterial walls is high, increasing the risk of heart attack and stroke. Blood pressure medications work by decreasing the body's release of adrenaline and other hormones that increase blood pressure, heart rate, and anxiety or by stimulating the brain to send nerve signals to the blood vessels, making them relax and widen. Two blood pressure drugs have been studied for the treatment of hot flashes: clonidine (sold under the brand name Catapres) and methyldopa (sold under the brand name Aldomet).

In randomized, double-blind, placebo-controlled trials, both medications helped to reduce the frequency of hot flashes by 46 to 80 percent in healthy women and those with breast cancer. Negative effects for clonidine and methyldopa include dizziness, unusual tiredness, and weakness. Check with your provider if you experience cold hands and feet; swelling of the ankles, feet, and lower legs; heart palpitations; or chest pain.

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