Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours?

Wijnands MV; van Erk MJ; Doornbos RP; Krul CA; Woutersen RA TNO Nutrition and Food Research, Department of Toxicology and Applied Pharmacology, Utrechtseweg 48, P.O. Box 360, Zeist, AJ 3700, The Netherlands. [email protected] The effects of different dietary compounds on the formation of aberrant crypt foci (ACF) and colorectal tumours and on the expression of a selection of genes were studied in rats. Azoxymethane-treated male F344 rats were fed either a control diet or a diet containing 10% wheat bran (WB), 0.2% curcumin (CUR), 4% rutin (RUT) or 0.04% benzyl isothiocyanate (BIT) for 8 months.

ACF were counted after 7, 15 and 26 weeks. Tumours were scored after 26 weeks and 8 months. We found that the WB and CUR diets inhibited the development of colorectal tumours.

In contrast, the RUT and BIT diets rather enhanced (although not statistically significantly) colorectal carcinogenesis. In addition, the various compounds caused different effects on the development of ACF. In ... more.

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