Do GST Polymorphisms Modulate the Frequency of Chromosomal Aberrations in Healthy Subjects?

Rossi et al. (2009) described an association between chromosomal aberration (CA) frequency and cancer risk in a case–control study on 107 cancer cases and 291 controls, whereby they observed no modifying effect of polymorphisms in glutathione S-transferase M1 (GSTM1) and GSTT1. In our studies of 488 healthy individuals who shared the same environmental exposure in Slovakia and the Czech Republic, we observed a CA frequency of 2.35 ± 1.73 (mean ± SD) (Halasova et al.

2007; Musak et al. 2008; Naccarati et al. 2006; Slyskova et al.

2007; Vodicka et al. 2001, 2004a, 2004b). The frequencies (mean ± SD) for chromatid-type abberations (CTA) and chromosome-type aberrations (CSA) were 1.22 ± 1.21 and 1.15 ± 1.35, respectively.

By analyzing modulating effects of genetic polymorphisms in GSTT1, GSTM1, and GSTP1 on CAs, CTAs, and CSAs (Table 1), we found no significant association between chromosomal damage and any of the studied polymorphisms. The results were further confirmed by logistic ... more.

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