Does giving glucocorticoids (prednisone or dexamethasone) to a dog/cat affect the results of the TLI/PLI?

We have no evidence that the administration of prednisone, prednisolone or dexamethasone alters the serum concentrations of TLI or PLI in a clinically significant manner in clinically healthy animals. Thus the administration of glucocorticoids is highly unlikely to lead to either increases or decreases in serum TLI or PLI concentrations that would alter your clinical diagnosis. If the animal has a disease causing malabsorption or increased release of pancreatic enzymes, and if the disease is glucocorticoid responsive, then abnormal values may become more normal or even normal when glucocorticoids are given.

This may influence your interpretation, and you should consider the possibility that a high normal or only moderately increased TLI or PLI, in an animal with clinical signs of pancreatic disease that is receiving glucocorticoid therapy, may have been higher in the absence of the glucocorticoids. The serum vitamins, cobalamin and folate, usually do not show any change with ... more.

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