Does the bone-marrow donor have to have the same blood type as the Leukemia patient?

No. The blood type doesn't matter. What does matter is that the donor and the recipient are HLA matched.

Human leukocyte antigen (HLA) typing is used to match patients and donors for bone marrow or cord blood transplants (also called BMT). HLA are proteins — or markers — found on most cells in your body. Your immune system uses these markers to recognize which cells belong in your body and which do not.

A close match between your HLA markers and your donor's can reduce the risk that your immune cells will attack your donor's cells or that your donor's immune cells will attack your body after the transplant. If you need an allogeneic transplant (which uses cells from a family member, unrelated donor or cord blood unit), your doctor will take a blood sample to test for your HLA type. A well-matched donor is important to the success of your transplant.

You inherit half of your HLA markers from your mother and half from your father, so each brother and sister who has the same parents as ... more.

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