How do you remove strong odor of urine on a mattress that has been urinated on 2-4 times a week for the past six months?

If the problem is going to continue and you don't want to change mattresses, put a thick vinyl mattress sack on it after cleaning and airing as well as you can. Then, use a mattress pad--get two so they can be washed. Perhaps also add an additional rubber pad under the sheet if there is a commonly used spot.

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