Hi I prefer having a more powerful single graphics card rather than a couple of slightly less powerful ones. A lot of games are not optimized for more than one graphics cards, so you often get issues with bad framerates and what we call "micro-stuttering". In this case, most of the time SLI has to be disabled and then the problems have gone, but then you are using a less powerful card.
For the games that it's optimized well for, are usually the games which were developed for the PC in mind primarily rather than the consoles. Also, with one more powerful card; energy consumption, heat and noise will be lower and you can also specify a less powerful power supply if you don't intend going for SLI in the future. Happy gaming :).
I would personally go with the GTX 780. You won't run into issues and you won't use more power, it would also be a heating issue if you have two graphic's card running at the same time and pretty noisy.
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