If I keep my house too clean, will it weaken my child's immune system?

Theoretically, yes. But practically and realistically, no. This misconception began circulating some years ago, thanks to magazine articles about overzealous parenting (though these probably made people feel better about blowing off housecleaning).

If you lived in a sterile environment, your child’s immune system would not develop properly. All humans need exposure to common, everyday bacteria, viruses, and garden-variety germs to develop a strong immune system and build up immunities. But unless you clean your house nearly twenty-four hours a day with antibacterial chemicals, rarely let your child outside, shun visitors, and never allow other people to touch your child, you can’t stop the necessary germ bombardment.

You can still blow off housecleaning. Just use a different excuse. From The Smart Parent's Guide: Getting Your Kids Through Checkups, Illnesses, and Accidents by Jennifer Trachtenberg.

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