In systems of 1000 gallons or larger, should the ozone applied be based on flow rate through the treatment unit (skimmer) or based on the total system volume?

Mmm, both and with consideration to the bio-loads... it would be better/best to have a variable/adjustable ozone generation, delivery system... of a few gram per hour capacity... and a desiccator... more.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.