Is aberrant neuronal plasticity related to previously identified abnormalities of neuronal inhibition?

Exactly what caused neuronal plasticity to transgress normal boundaries in writer's cramp remains unknown. Because our protocol comprised activation of an afferent somatosensory pathway as well as external activation of the motor cortex, the spatial abnormalities of PAS-induced plasticity could be due to a disturbance in any neuronal processing stage before or within the motor cortex. Indeed, previous findings have provided evidence both for spatial de-differentiation of somatosensory representation (Bara-Jimenez et al.

, 1998; Elbert et al. , 1998; Tinazzi et al. , 2000) and for a disturbance of sensorimotor integration (Abbruzzese et al.

, 2001; Tamburin et al. , 2002; Bertolasi et al. , 2003) in dystonia.

However, while somatosensory de-differentiation may contribute to spatial de-differentiation in motor cortex, it would not easily explain the increased gain of motor cortical plasticity. Deficiencies in homeostatic dynamic plasticity mechanisms such as synaptic scaling (Turrigiano and ... more.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.