Is GERD an Exacerbation Factor for Asthma?

Gastroesophageal reflux disease (GERD) and asthma are common as independent conditions, and GERD is present in 34 to 90 percent of patients with asthma. Little is known about the way these two conditions co-exist or the way GERD exacerbates asthma. Various antireflux treatments, including medical and surgical management, have been shown to improve asthma control in some patients.

Multiple tests are available to confirm a diagnosis of GERD, including barium radiographs and upper gastrointestinal endoscopy. O'Connor and colleagues evaluated a variety of methods for diagnosing GERD to determine which is most cost-effective. The study population consisted of middle-aged adults with moderate to severe asthma and heartburn at least once a week.

A cost-effectiveness analysis was performed on 11 different diagnostic strategies using a combination of 24-hour pH monitoring and omeprazole therapy, or omeprazole alone. The strategies were divided into three categories: pH testing followed by ... more.

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