The MIC is the minimal inhibitory concentration of an antimicrobial agent MIC's are used to assess the dosage of antimicrobial necessary to inhibit the growth of organisms. How is a MIC performed and how is this related to laboratory mathematics?

MICs can be performed on broth, agar, tubes, or microtiter plates and employ the concept of serial dilution we studied at the beginning of the course. In the macro tube method, an equal amount of suspended bacterial growth is added to 12 tubes. Then a serial dilution of the antimicrobial agent to be tested is performed in the tubes containing the suspended bacteria.

The MIC is the lowest concentration in which there is no visual growth of the organism. Copyright 1999, Hartnell College. All rights reserved.

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