What are some of the functions of glutathione (gsh)?

Refs. 1--5 • Maintains proper oxidation-reduction (redox) potential inside cells. Redox affects the oxidation state of sulfur in enzymes, and thus affects the rates of biochemical reactions in cells.

• Scavenges peroxides and oxidizing free radicals directly and also serves as the basis for the antioxidant network. • Performs Phase II detoxication of heavy metals (such as mercury), organophosphate pesticides, chlorinated hydrocarbon solvents, estradiol, prostaglandins, leukotrienes, acetaminophen, and other foreign and endogenous toxins. • Stores and transports cysteine throughout the body.

• Transports amino acids, especially cystine into kidney cells. • Regulates the cell cycle, DNA and protein synthesis and proteolysis, and gene expression. • Regulates signal transduction.

• Participates in bile production. • Protects thyroid cells from self-generated hydrogen peroxide. In carrying out several of the above functions, GSH plays very important roles in (1) maintaining ... more.

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