It should be noted that Ruth's home run record, both single season and a career, were more the result of the changing times and not an extraordinary feat. Bonds 73 home runs came in a season where the 'average' player hit 20. When Ruth hit 59, the average hitter hit 3.79.
Bonds would have had to hit close to 200 home runs in 2001 to mimic Ruth's feat. As far as your question goes, Home run, RBI and Run records will always fluctuate. Even when Arod takes these over, he won't keep them for ever.
Single season records that are likely in no danger would be: Owen Wilson's 36 triples, Rickey Henderson's 130 SB Dimaggio's 56 game hitting streak Hornsby's .424 batting average. Ruth's 457 total bases may be hard to touch, especially since Bonds' 73 HR season only netted him 411 (but he came 3rd that year to Sosa and Luis Gonzalez) Ruth's 177 Runs Chesbro's 41 wins Ed Walsh's 464 IP Chesbro's 51 GS or his 30 CG For a period of time, I doubt that anyone could come close to 5 year time span and ... more.
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