What role has Fred Hutchinson Cancer Research Center played in the development of bone-marrow and stem-cell transplantation?

At the time the Hutchinson Center was founded in 1972, basic research that would lead to the treatment we now know as bone-marrow or stem-cell transplantation had been in process for nearly 40 years. Transplants between identical twins, because they have identical genetics, had been successful for more than 10 years. However, many difficult challenges remained and advances were slow in coming.

Recurrent leukemia, problems of graft failure, failure to eradicate the disease, infection and graft-vs.-host disease (GVHD) meant that the treatment was still a highly experimental last resort for the dying. When the Center opened its new facility in 1975, the primary clinical focus was the pioneering work of Dr. E. Donnall Thomas in bone-marrow transplantation.

Thomas' work, which was considered radical at the time, had attracted scientists from around the world. The Center became the recognized leader in the field of bone-marrow transplantation. Since that time, the work of the Center has ... more.

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