310 East 67th Street is between 2nd and 1st Avenue, closer to 2nd. Take the A-C-E (the blue line) or the 1-2-3 (the red line) ONE stop Uptown, from 34th Street (Penn Station) to 42nd Street (Times Square) At the Times Square Station, transfer to the S shuttle train (color code grey) east across 42nd Street, from Times Square (West 42nd) to Grand Central Station (East 42nd) At Grand Central, get on the Uptown 6 train (of the 4-5-6, the dark green line) to 68th Street-Hunter College You will get off the train on the east side of Lexington Avenue. Walk east until you get to 2nd Avenue See the Related Link below for a complete New York City subway map.
You can take the Uptown E train (of the A-C-E the blue line) from 34th Street-Penn Station to 53rd Street-Lexington Avenue. Transfer is available from this station to the 51st Street Station on the 6 train (of the 4-5-6 the dark green line). Walk through the tunnel that connects the two stations, and take the Uptown 6 to 68th Street-Hunter College (at Lexington Avenue) There's another route that requires less walking, but requires you to go Downtown and then back Uptown: take the Downtown A C or E from 34th Street-Penn Station to West 4th Street.
Transfer at West 4th Street to the Uptown F (of the B-D-F-M the orange line) and take the F to 63rd Street-Lexington Avenue.
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