Tay-Sachs Disease was first recorded by Warren Tay in 1881, and then first described by Bernard Sachs in 1887. The first family to be affected by this disease was the family of Rabbi Josef Ekstein in Brooklyn. You can find more information here: whonamedit.com/synd.cfm/455.html.
John S. O'Brien M.D. is the person responsible for discovering the gene which is responsible for the genetic mutation called Tay Sach's disease. You can find more information here: genetic-diseases.net/tay-sachs-disease.
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