Do animal models of ALS or other neurodegenerative diseases accurately represent human symptomology and brain pathology?

A. Not exactly. A post-doc in my lab once told a famous neuroscientist, "Well, maybe humans are a poor model of the mouse disease!"

But they're the most accepted model available and can teach us many things. Q. Are there other substances that may be important in preventing the development of these diseases?

A. We know from epidemiological studies that nonsteroidal anti-inflammatory drugs may be protective in some forms of neurodegeneration. For example, people who have arthritis and take an NSAID or other antiinflammatory drug have a much lower risk of Alzheimer's disease.

Paired-twin studies yielded similar results. People with elevated uric acid, such as those with gout, have a much lower incidence of multiple sclerosis, and scientists have found similar correlations for Parkinson's disease. Q.

If some of these substances reduce the risk for these diseases, does that suggest that they also may be useful in slowing the progression or even reversing the disease? A. That's been ... more.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.