ITunes allows users to restore iPods, iPhones, and iPads so you're less likely to permanently lose saved data. You can decide to do a restore but if you do, remember that there's a limited amount of storage space available and the performance of any computer will inevitably degrade as it's available space is used up. A potential option in for you would be start with a clean device with no apps installed and then install only the apps you use frequently.
For example I have over 250 apps but I only have 30 on my iPhone because I don't use the others. Another important factor to consider is if you'll use your iPad to consume media e.g. Movies, music, books, etc.Apple uses DRM or Digital Rights Management software to guard against piracy. This means if you delete media from your iPad, it can be difficult to reinstall it without repurchasing.
So the answer to your question depends on how you'll use your iPad. If it's primarily going to be used for streaming and apps, it's probably better to set up as new, but if you have a lot of music or movies, it's best to restore from the backup. I hope this helps.
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